Mani Pavuluri, M.D., Ph.D., University of Illinois at Chicago
Standard Research Grant (2008): $63,750
fMRI Study of Brain Circuitry Underlying Impulsivity and Affect Regulation in Suicidal Patients with Adolescent Bipolar Disorder
Abstract: This study proposes to use functional magnetic resonance imaging (fMRI) to map brain circuitry in high risk patients with adolescent bipolar disorder (ABD). The primary aim is to unravel the functional neurobiology of impulsivity and negative emotion regulation, factors known to be associated with completed suicide in this population. Subjects will include 60 youth (aged 13-18) with ABD, 30 who have made a suicide attempt and 30 who have not. The investigator hypothesizes that suicidal ABD subjects will show greater abnormalities in the fronto-limbic (emotional) circuitry and fronto-striatal (response inhibition) circuitry, compared to non-suicidal ABD patients. It is hoped that findings from the study will lead to the identification of a cluster of biomarkers in bipolar risk at high risk for suicide, and to the development of interventions that can reverse the neural dysfunctions to prevent suicide.