Michael McCloskey, Ph.D., Temple University
Standard Research Grant (2010): $75,000
Neural Substrates of Emotion Dysregulation and Self-Harm in Suicide Attempters
Abstract: The study will investigate fMRI signals from borderline personality disorder females who will engage in tasks during the MRI designed to elicit emotional responses relating to self aggression and suicidal behavior. This work will provide the brain circuitry associated with the failure to regulate negative emotions and the initiation of self-harming behavior in a group of previously suicidal women with borderline personality disorder. While undergoing the fMRI scan the individuals will be subjected to emotionally evocative pictures and a stimulus emulating self-harm. The difference between suicidal and non-suicidal subjects in the limbic and cortical areas of brain activation will be compared to identify patterns of brain activation associated with suicide risk. This is an important investigation targeting core issues of the neurobiology of suicide. No one has done this before, thus highly innovative.